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Dear Colleagues:

We are pleased to announce that the 12th Annual Symposium on Antiviral Drug Resistance: Targets and Mechanisms will be held November 6-9, 2011, at The Hotel Hershey in Hershey, Pennsylvania.

Effective antiviral therapy is the only hope for survival or alleviation of disease for millions of Americans and tens of millions of individuals worldwide suffering from chronic viral infections, including those caused by HIV, HBV, HCV, and others. In addition, there is a continuing threat of global outbreaks from influenza and other newly appearing or resurgent viruses. Despite considerable progress in the development of effective inhibitors that target specific aspects of viral life cycles, therapeutic efficacy has been limited by the evolution of resistant virus. This problem not only results in the failure of therapy, but may limit the effectiveness of subsequent therapies. Moreover, attempts to counter drug resistance lead to complex, expensive, and toxic regimens. Antiviral drug resistance is therefore of paramount importance in dealing with growing epidemics caused by virus infection.

The Symposium on Antiviral Drug Resistance: Targets and Mechanisms brings together researchers studying a variety of virus systems to exchange new information on viral targets for therapy, on antiviral drugs, and on drug resistance. We believe that understanding the similarities and differences in diverse viral systems will lead to new insights into the problem of resistance in each individual virus.

The focus of the Symposium is on specific molecular targets, their normal structure and function, their interactions with antiviral drugs, and the evolutionary basis and specific mechanisms of viral resistance. Organized by molecular target, the program will include invited speakers as well as oral and poster presentations selected from submitted abstracts. The covered topics include:

small teal arrowhead pointing to right  Biology of Viral Infection
small teal arrowhead pointing to right  Viral Entry
small teal arrowhead pointing to right  Nucleic Acid Replication
small teal arrowhead pointing to right  Integration
small teal arrowhead pointing to right  Host Factors in Viral Replication
small teal arrowhead pointing to right  Novel Antiviral Strategies
small teal arrowhead pointing to right  Assembly, Release, and Processing
small teal arrowhead pointing to right  Microbicides and Other Preventive Strategies

This Symposium is sponsored by the University of Pittsburgh and co-sponsored by the HIV Drug Resistance Program of the National Cancer Institute. Through the generous support of corporate sponsors, financial assistance is available to a limited number of postdoctoral fellows, students, and other non-physician researchers whose abstracts are selected for presentation but who are not in the position to support their own participation in the Symposium. If you are interested in applying for such financial assistance, click here for more information.

We hope you will join us in November for what promises to be a terrific 12th edition of this Symposium series.

John W. Mellors, M.D.
Division of Infectious Diseases
University of Pittsburgh

John M. Coffin, Ph.D.
Tufts University
(on contract to HIV Drug
Resistance Program, NCI)

Stephen H. Hughes, Ph.D.
HIV Drug Resistance Program
National Cancer Institute



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